An extremely rare case of chondromyxoid fibroma of the zygomatic arch in a 65-year-old woman is presented. Block resection and immediate reconstruction were done with calvarial bone with fixed with microplate and screws through the hemicoronal approach. Follow-up studies have shown no tumor recurrence for 7 years. Also, we carried out an immunohistochemical study. The results showed positive S-100 and vimentin staining, while showing only very weak staining for NSE. The Ki-67 staining study showed a PI-index of only 0.67%.