There are many types of reduction drives for industrial uses. However, it is essential to use precision reduction drives for accuracy of position controls on robot systems. Among the precision reduction drives, the cycloid reduction drive is well known for its high performances and widely used in precision industrial field. Cycloid reduction drives are mainly used in manipulators in robot system requiring a characteristic of a high precision control. When we design this cycloid reduction drive, there are many factors that must be considered. First, a geometrical analysis of a tooth shape must be drawn from the basic concept. Secondly, load distribution, stress distribution and sliding velocity on a tooth should be calculated exactly. Finally, a computer software to optimize the design of a cycloid tooth needs developing. In this study, many different kinds of factors concerning the characteristic of a cycloid tooth were researched on the basis of the analysis of load, stress and sliding velocity on a tooth. The computer expert system to design the cycloid reduction drive was developed using a Visual C++ compiler. In conclusion, the most important factors can be obtained easily as the user put the simple input data.