China’s aviation cargo transportation has developed rapidly in recent years, airport logistics is the outcome of modern logistics and high-efficiency of traditional aviation cargo transportation. Because of the speed, convenience and safety of airport logistics, people increasingly tend to use airports to carry out activities in all aspects of logistics, the demand for airport logistics has exploded, and airport logistics has become an important factor to be considered in airport planning and later development now. The development of airport logistics has created the airport economy, the rise of the airport economy has become a new growth pole of the regional economy. At present, the construction of high-speed rails has caused bottlenecks in the development of aviation cargo transportation, and the advantages of airport logistics have been greatly weakened, therefore, airport logistics must find a solution out. Therefore, on the basis of summarizing the relevant literature, this article closely links airport logistics with related local industries, and seeks a new way for the coordinated development of airport logistics and regional economy. This article takes the Pudong New Area and Pudong Airport as examples to explore the driving factors for mutual boosting development between airport logistics and regional economy. Based on this, select Granger causality test to prove the causality between Pudong airport logistics and Pudong economy, and use the gray relational theory to calculate the gray relational degree of Pudong airport logistics and Pudong economy. According to the results of empirical analysis, summarized propose corresponding recommendations and provide effective suggestions for the Pudong government and related enterprises to promote coordinated development of airport logistics and regional economy.