Deep borehole drilling is essential not only to select the host rock type for deep geological disposal of high-level radioactive waste (HLW), but also to identify the characteristics of the disposal site during the site selection process. In particular, since the disposal depth of HLW is considered to be over 300 m, deep borehole drilling must be performed. In deep borehole drilling, drilling design, excavation, and operation may vary depending on the rock type, drilling depth, and drilling purpose etc. This study introduced cases in which Korea was divided into four geotectonic structures and four representative rock types and conducted with a goal of 750 m drilling depth. Prior to this, a review of deep drilling cases conducted at domestic and abroad was presented. If sufficient time and cost are available, several drilling holes can be excavated for various purposes, but if not, one or two drilling holes should be used to achieve the objectives of various fields related to HLW disposal. The presence of bedding, strata or fault zones depending on the type of rock, etc. may affect drilling deviation or circulating water management. In addition, unlike drilling in general geotechnical investigation drilling, the use of polymers or grouting agents is limited to determine hydraulic and geochemical characteristics. This report introduces the experience considered during the design and drilling process of deep drilling in granite, gneiss, sedimentary rock, volcanic rock, etc., and is expected to be used as basic data when carrying out future HLW projects.