Methanol was directly produced by the partial oxidation of methane with four-component mixed oxide catalysts. Four-component(Mo-Bi-Cr-Si) mixed oxide catalysts were prepared by the co-precipitation and sol-gel methods. The catalyst prepared by the sol-gel method showed about eleven times higher surface area than that prepared by the co-precipitation method. From the O2-TPD experiment of the prepared catalysts, it was proven that there exists two types of oxygen species, and the oxygen species that participates in the partial oxidation reaction is the lattice oxygen desorbing around 750℃. The optimum reaction condition for methanol production was 420°C, 50 bar, flow rate of 115 mL/min, and CH4/O2 ratio of 10/1.5, providing methane conversion and methanol selectivity of 3.2 and 26.7%, respectively.