Purpose: This study aimed to develop an algorithm-based simulation scenario for emergency measures for a high-risk newborn presenting apnea. Methods: A methodological study design was used to develop the algorithm-based simulation scenario. Expert evaluation was used to establish the developed algorithm’s content validity. Results: The simulation scenario was developed using several steps of algorithm development based on the Neonatal Resuscitation Program (NRP). The content validity was established. Based on the expert evaluation results, an eight-frame algorithm was selected for the final simulation scenario. The scenario courseware was composed of six major components: pre-learning activity simulation orientation, simulation operation, SBAR-format recording, watching the video-clip of their performance for self-evaluation and debriefing. After simulation, student’s clinical performance and communication skill were evaluated with the developed instrument. Conclusion: Considering that nursing students have limited access to high-risk newborns during their clinical experience and that newborns presenting apnea are common in the neonatal intensive care unit, the algorithm-based simulation scenario developed in this study can provide students with the opportunity to practice alternative emergency measures for high-risk newborns.