As human's average lifespan is gradually increased, the interest in the quality of life and health is also increasing. More and more customers like to use the facial manual technique as a way to live a healthy life, instead of using it as measures to simply improve skin troubles or to have beautiful skin. The facial manual technique performed in the skin care stage is closely related to the decrease of stress. In order to verify the effects of facial manual technique on the decrease of stress, an experiment was conducted in the same method by dividing 16 women residing in Seoul into four groups, from September 1st to September 30th 2016. To understand their general characteristics, perceptual stress, and satisfaction with facial manual technique through questionnaire, the frequency analysis and descriptive statistics were performed by using SPSS 22.0 program. The paired t-test was conducted to see changes in stress, LF, HF, LF/HF, average pulse, pulse standard, and average deviation before/after experiment. The stress index was decreased in every group. Especially, the group of the 20s showed a huge decrease(24.3%), which was significant to every group except for the 50s. In the results of LF, the group of the 20s and of the 30s increased 2.8% and 4.6% respectively, which was significant. In the group of the 40s, it was increased 4.0% while it was decreased 1.2% in the 50s. Rather than women in climacteric age, it was more effective for women in younger age. In results of pulse standard, it was increased 36.5% in the 20s, 63.6% in the 40s respectively, which was significant(p<0.05, p<0.01). In the group of the 30s and 50s, the significant values were not shown although it was still increased 48.3% and 65.1% respectively. In the survey of the facial manual technique, the whole participants showed positive responses to its effects on the decrease of stress. A majority of them took easy to control feelings, and it was highly possible for them to use it perio-dically in the future. It suggested that the effects of facial manual technique could play a role on recovering psychological stability and decrease of stress. It could be considered as a safe and effective healthcare method to improve the quality of human's life.