Seismic qualification of instruments and devices mounted on electrical cabinets in a nuclear power plant is performed in this study by means of the in-cabinet response spectrum (ICRS). A simple method and two rigorous methods are proposed in the EPRI NP-7146-SL guidelines for generating the ICRS. The simple method of EPRI can give unrealistic spectra that are excessively conservative in many cases. In the past, the time domain analysis (TDA) methods have been mostly used to analyze a structure. However, the TDA requires the generation of an artificial earthquake input motion compatible to the target response spectrum. The process of generating an artificial earthquake may involve a great deal of uncertainty. In addition, many time history analyses should be performed to increase the accuracy of the results. This study developed a numerical analysis program for generating the ICRS by frequency domain analysis (FDA) method. The developed program was validated by the numerical study. The ICRS calculated by FDA thoroughly matched with those obtained from TDA. This study then confirms that the method it proposes can simply and efficiently generate the ICRS compared to the time domain method.