A primary infection with Toxoplasma gondii is usually asymptomatic, but some patients may have cervical lymphadenopathy and ocular disease. Toxoplasmosis is a common cause of lymphadenopathy. However, histopathologic examination to diagnose it usually does not reveal toxoplasmic cysts. Diagnosis of toxoplasmosis can be established by serological techniques or by direct detection of the parasite. Therefore, it is necessary to recognize the characteristic histopathological findings of toxoplasmic lymphadenitis and to confirm by serological or PCR results for toxoplasmosis. We describe histopathologic features of a case of toxoplasmic lymphadenitis with review of the literature, confirmed by serological evidence in a 50-year-old man.