Food hazards caused by Hazard Analysis Critical Control Point(HACCP) products are closely related to the failure of prerequisite program. ISO 22000 introduced the Operational Prerequisite Program (OPRP) to enhance management of the prerequisite program. This program has started to strengthen discriminatory management of hazards identified as high in risk analysis but not selected as Critical Control Points. In addition, the US-FDA has begun to apply Food Safety Modernization Act (FSMA) obligations to all foods manufacturing and distribution including imported foods. The basic concept of the FSMA is Hazard Analysis and Risk-based Preventive Control (HARPC), which is similar to the OPRP. It is necessary to strengthen the management of the prerequisite program by using the OPRP or HARPC concept, which will improve the effectiveness of HACCP operation.