We developed two heuristic methods to solve the problem considering a fleet of ships delivering chemical products from terminals We need to decide how much of each product to carry, on which ship, subject to the conditions that all terminals must have suf

The inventory routing problem (IRP) is an important area of Supply Chain Management. The objective function of IRP is the sum of transportation cost and inventory cost. We propose an Artificial Immune System(AIS) to solve the IRP. AIS is one of natural computing algorithm. An hyper mutation and an vaccine operator are introduced in our research. Computation results show that the hyper mutation is useful to improve the solution quality and the vaccine is useful to reduce the calculation time.