Amyloidosis is a disease caused by extracellular deposition of the fibrous protein amyloid in one or more sites of the body, leading to organ dysfunction and death. Its causes and pathogenesis are variable, with common histopathologic features. Amyloidosisis a rare disease, and usually present in the heart and frequently in the gastrointestinal tract, skin but is rarely encountered in lymph nodes. Amyloidosis in Waldenström’s macroglobulinemia (WM) is exclusively due to amyloid lightchain deposition. Only a few case of amyloidosis in WM have been reported. We report on one case that occurred independently of with Primary amyloidosis which involved only multiple lymphadenopathy and waldenstrom’s microglobulinemia involving bone marrow.