This study examines factors influencing occupational injuries among plant and machine operators using the Semi-supervised MarginBoost algorithm. Data from the 2007-2009 Korean National Health and Nutrition Examination Survey (KNHANES) were analyzed, covering 4,062 employed participants. The MarginBoost model achieved 84.3% accuracy, outperforming other models. Key factors identified included exposure to hazardous substances, ergonomic conditions, and psychosocial stress. The findings emphasize the need for targeted interventions to enhance workplace safety and offer a robust predictive tool for the effective management of occupational health.