In this paper, we study the existing results of the structure-soil-structure interaction (SSSI) effect on seismic responses of structures and summarize important parameters. The parameters considered in this study are a combination of buildings in the power block of a nuclear power plant, the characteristics of earthquake ground motions and its direction, and the characteristics embedded under the ground. Based on these parameters, the seismic analysis model of the structures in the power block of the nuclear power plant is developed and the structure-soil-structure interaction analyses are performed to analyze the influence of the parameters on the seismic response. For all analyses, the soil-structure interaction (SSI) analysis program CNU-KIESSI, which was developed to enable large-sized seismic analysis, is used. In addition, the SSI analyses is performed on individual structures and the results are compared with the SSSI analysis results. Finally, the influence of the parameters on the seismic response of the structure due to the SSSI effect is reviewed through comparison of the analysis results.