As the hydrofluoric acid leak at Gumi-si, Gyeongsangbuk-do or hydrochloric acid leak at Ulsan demonstrated that chemical related accidents were mostly caused by large amounts of volatile toxic substances leaked due to the damages of storage tank. The purpose of this study was to develop PFA lined bottom drain ball valve for using in semiconductor, LCD manufacturing fields, pharmaceutical and others. For this purpose, modeling and design of PFA lined bottom drain ball valve, casting mold and casting production, design and manufacturing of lining mold, design and manufacturing of lining jig, PFA forming and assembly have been carried out for 50A×25A PFA lined bottom drain ball valve. In addition, a performance test was performed for the pin hole, density, tensile strength, elongation and elastic modulus of the developed prototype. As a result, the performance of the prototype valve satisfies all the objects of this study. Also, the developed valve was a very good performance compared with conventional 50A×25A imported valve with the same size.