During the screening program to evaluate the antiallergic activity of herbal medicines, Schizandra chinensis was found to inhibit the mouse PCA reaction induced by IgE-antigen complex. To evaluate the antiallergic effect of the fruit of Schizandra chinensis Baill (Family Magnoliaceae), which attenuate compound 48/80 induced vascular permeability reaction and scratching frequency in mouse. and it also inhibited 43% acute type of contact dermatitis induced by TPA and in oxazolone induced chronic dermatitis model was investigated. Fruit of Schizandra chinensis suppressed 37.6% swelling of oxazolone-induced mouse ear contact dermatitis. These findings suggest that fruit of Schizandra chinensis improve symptom of allergic dermatitis