파장변이섬유를 사용한 새로운 반응 위치 측정 양전자방출 단층촬영기기 검출기를 개발하였으며, 이에 대한 최적화 작업을 수행하였다. 섬광체 2개와 파장변이섬유 3개를 사용하고, 파장변이섬유 끝에 센서를 부착하여 최적화 모듈을 설계하였다. 섬광체와 파장변이섬유 및 센서를 연결시키는 연결물질과 섬광체와 파장변이섬유의 반사체 물질에 따른 센서에서의 빛 수집율 및 센서별 빛 수집 비를 통해 최적의 조합을 도출하였다. 연결물질은 에폭시를 사용하고 반사체 물질은 섬광체와 파장변이섬유에서 각각 난반사체 및 거울반사체를 사용한 조합에서, 가장 높은 빛 수집율과 센서별 빛 수집 비를 보였다.

A case of three primary malignancies in one patient is rare. We report on a case of three primary malignancies including myxofibrosarcoma, renal cell cancer, and prostate cancer in one 18F-fluorodeoxyglucose (FDG) positron emission tomography/ computed tomography (PET/CT) evaluation of a 75-year-old man. PET/CT showed different FDG meabolism in each tumor.

We compared the results of early follow-up of F-18 FDG PET/CT and MRI performed within one month after radiation therapy for cervix cancer patients. We conducted a retrospective review of the clinical data of cervix cancer patients whose PET/CT and pelvic MRI performed at staging and within one month from the end of RTx. SUVmax on PET/CT and size on MRI of the primary tumor were analyzed. We compared %change of SUVmax and size between staging and follow-up. A total of 27 patients were enrolled. At staging, larger tumor showed high SUVmax. At follow-up, no significant correlation was observed between size and SUVmax. In 77.8% of patients, changes in SUVmax were well correlated with changes in size. No correlation was observed between % change and value at staging in both SUVmax and size. Except for six patients who showed significant FDG uptake without evidence of a mass on MRI, % changes of size and SUVmax were well correlated. Metabolic change can be accessible on early follow-up PET/CT at±1 month from the end of the RTx of cervix cancer. However, careful interpretation of PET/CT is needed due to possible radiation-induced hypermetabolism even without a definite mass on MRI.