About 80% Of animal species represents insect species, which recently became important biological model animals due to the development of genetic modification technology, where genetically modified insects are used for basic to applied research such as agriculture and biomedical purpose. Therefore, confinement of biosafety level and guideline are recommended and required in order to make it possible for well-maintained and world-standard research environment using these LMO insect models. The main goal of this study focuses on setting up the biosafety practice and policy for insect research facilities and their guideline for establishment and management.