The number of children who use day-care centers is increasing. Most indoor air quality (IAQ) management has been based on daily average pollutant concentrations measured once a year. A more comprehensive management of IAQ is needed to protect children’s health from air pollutants in day-care centers. In this study, we investigated the weekly variation of air pollutant concentrations in a nursing room of a day-care center located at the roadside for a week in June of 2014. Average concentrations of CO2, PM10, black carbon, and total surface area of lungdeposited particles during nursing time of the day-care center were 510 ppm, 27.8 μg/m3, 1.87 μg/m3, and 30.6 μm2/cm3, respectively, with a similar diurnal pattern shown on weekdays.