The objective of this study is to evaluate the structural safety of the spherical-helical turbine for hydro-power. We analyze fluid-structure interaction of the spherical-helical turbine for hydro-power using ANSYS-CFX and Mechanical. The maximum combined stress, deformation and safety factor of the spherical-helical turbine in cases of three types of materials were obtained by fluid-structural analysis. From structural analysis, the maximum value of the equivalent stress occurred at the shaft of the turbine for three material types. In case of a polyethylene turbine blades, the maximum equivalent stress and safety factor were 3.46 MPa and 7.23. Polyethylene turbine blades were evaluated to be safe except of the turbine shaft. Several researches will be performed based on the results of this study and more research and development of technologies are needed in this field.