Exudative epidermitis (EE) is a generalized skin disease of pigs, mainly caused by Staphylococcus hyicus (S. hyicus). Antibiotic resistant S. hyicus leads to the failure of antimicrobial treatments. This necessitates proper identification of the strains in the field and determination of their antimicrobial susceptibility. This study was carried out to isolate Korean S. hyicus and determine its antimicrobial resistance. Isolate was sensitive to ceftiofur, ciprofloxacin, enrofloxacin, gentamicin, neomycin, and tylosin, but remarkably resistant to amoxicillin, lincomycin, penicillin, streptomycin, and tetracycline. Our study contributes to the understanding of the characteristics and antimicrobial resistance of Korean S. hyicus, which in turn will provide an antimicrobial treatment strategy to control EE.