Coupled thermo-hydraulic-mechanical (THM) processes are essential for the long-term performance of deep geological disposal of high-level radioactive waste. In this study, a numerical sensitivity analysis was performed to analyze the effect of rock properties on THM responses after the execution of the heater test at the Kamaishi mine in Japan. The TOUGHFLAC simulator was applied for the numerical simulation assuming a continuum model for coupled THM analysis. The rock properties included in the sensitivity study were the Young’s modulus, permeability, thermal conductivity, and thermal expansion coefficients of crystalline rock, rock salt, and clay. The responses, i.e., temperature, water content, displacement, and stress, were measured at monitoring points in the buffer and near-field rock mass during the simulations. The thermal conductivity had an overarching impact on THM responses. The influence of Young’s modulus was evident in the mechanical behavior, whereas that of permeability was noticed through the change in the temperature and water content. The difference in the THM responses of the three rock type models implies the importance of the appropriate characterization of rock mass properties with regard to the performance assessment of the deep geological disposal of high-level radioactive waste.

In this study, skin permeation enhancement was confirmed by designing it to have a structure and composition similarity to the intercellular lipids that improve miscibility with skin by cross-linked lipids poloxamer. The cross-linked lipids poloxamer was synthesized and analyzed by 1H NMR that structure dose had conjugated pluronic with ceramide3. Active component is released by modification of liquid crystal structure because PPO part, large-scale molecule block of pluronic, has hydrophobic nature at skin temperature of 35℃. Conjugated pluronic with ceramide3 was synthesized using Pluronic F127 and p-NPC (4-nitrophenyl chloroformate) at room temperature yielded 89%. Pluronic(Ceramide 3-conjugated Pluronic) was synthesized by reaction of p-NP-Pluronic with Ceramide3 and DMAP. The yield was 51%. This cross-linked lipids poloxamer was blended and dissolved at isotropic state with skin surface lipids, phospholipid, ceramide, cholesterol and anhydrous additive solvent. Next step was preceded by α-Transition at low temperature for making the structure of Meso-Phase Lamella, and non-hydrous skin analogue liquid crystal using thermo-sensitivity smart sensor, lamellar liquid crystal structure through aging time. For confirmation of conjugation thermo-sensitivity smart sensor and non-hydrous skin analogue liquid crystal, structural observation and stability test were performed using XRD(Xray Diffraction), DSC(Differential Scanning Calorimetry), PM (Polarized Microscope) And C-SEM (Cryo-Scanning Electron Microscope). Thermo-sensitivity observation by Franz cell revealed that synthesized smart sensor shown skin permeation effect over 75% than normal liquid crystal. Furthermore, normal non-hydrous skin analogue liquid crystal that not applied smart sensor shown similar results below 35℃ of skin temperature, but its effects has increased more than 30% above 35℃.