The purpose of this qualitative study is to examine the literatures about human health effects due to the climate change and ozone depletion since 1990s. Over the past decade climate becomes an increasingly significant factor in world affairs because of its effect on food supplies, energy consumption, environmental quality and natural hazards etc. Simultaneously the scientific associations have had to reappraise the nature and scope of climatology, increasing political relevance, leading to a growth in interdisciplinary research involving natural and socioeconomic scientists. The 2000s promise to continue this broadening of scope as the three-way interaction of human society, medical system and atmospheric system are further explored and evaluated. This paper reviews this trends, paying particular reference to climate-based environmental concerns and human health effects being debated.