The purpose of the study was to develop clothing that enhances comfort for children using gastrostomy tubes while maintaining a design that is no different from that of non-disabled children. The discomfort experienced by children with gastrostomy tubes wearing regular daily clothing was investigated through medical papers and blogs of their parents. The designs were then created to address the issues. The results were as follows: Because the location of the gastrostomy tube is in the upper body, four types of clothing items were developed: one sweatshirt for boys, two one-piece dresses for girls, and one windbreaker suitable for both boys and girls. Considering practicality for children’s clothing, cotton fabric was prioritized. For sweatshirts and windbreakers, a patched pocket with a dog pattern was placed over the area containing the gastrostomy tube to hide it. Frills were used to conceal the gastrostomy tube in one-piece dresses and designed to allow easy access for eating or disinfecting the area. This study aimed to address the challenges children with gastrostomy tubes face when wearing the regular daily clothes of non-disabled children while also offering aesthetically pleasing designs that enhance convenience for those using gastrostomy tubes. We believe this study will not only raise public awareness of disabilities but also inspire research on future clothing for both children and adults using gastrostomy tubes.