At a two phase flow, according to gas and liquid phase flow rates, various flow regimes are developed such as bubbly, slug/plug, churn, annular, droplet flow and so on. At a two phase flow in small scaled channels, among various flow regimes, the intermittent flows such as bubbly, slug/plug flow are developed in the broad regions of two phase flow pattern map. In particular, the flow regimes are influenced by surface wettability. In a case of slug flow in hydrophobic small scaled channels, gas and liquid phases are perfectively separated by interfaces and contact line. The pressure drop of the two-phase flow is largely generated at moving contact line. Therefore, to well design two-phase flow system with small scales, it is important to estimate the pressure drop at moving contact line. In this study, on the basis of previous research, the pressure drop at moving contact line is experimentally measured for a various fluids (0-40% water-ethanol mixtures). And, the previous correlation to estimate pressure drop at moving contact line is verified by experimental data. In an addition, we discuss interfacial broken phenomena of slug flow in a minichannel. (D=1.555mm).