Anal Therapy is another way of taking medicine. It is a traditional pathway but not available in common situation. Nevertheless, It has many benifect and usefulness, it has not treated so much. As there are many kinds of Anal therapy, this study use retention type. Sochungyongtang (SCYT) has been known to be the most effective prescription largely applied to bronchial asthma, whooping cough, pneumonia, pleurisy, nephritis and arthritis and so forth. In this study, the author investigated the effect of an aqueous extract of SCYT by Anal therapy (Retention Enema) in immediate type allergic reaction. The following results were obtained 1. Retention Enema of SCYT showed a marked inhibition rate in systemic immediate-type allergic reaction with a dose of 1000 mg/kg 1 hr before intraperitoneal injection of compound 48/80. 2. SCYT significantly reduced serum histamine contents induced by compound 48/80. SCYT (1000 mg/kg) also inhibited to 64.11±19.86% (P<0.01) local immediate-type allergic reaction activated by anti-dinitrophenyl (DNP) IgE. 3. In addition, SCYT dose-dependently inhibited the histamine release from the peritoneal mast cells by compound 48/80 or anti-DNP IgE. These results provide evidence that anal therapy (Retention enema) of SCYT may be beneficial in the treatment of systemic and local immediate-type allergic reaction.