The high-level nuclear waste (HLW) repository disposes of high-level nuclear waste at a depth of 500 m to 1,000 m underground. Structural health monitoring must be accompanied by the complex environmental conditions of high temperature, high humidity, radiation, and mechanical stress. A thermocouple for measuring temperature, total stress meter and pore pressure meter for measuring stress and water pressure, relative hygrometer and electrical resistivity sensor (TDR or SUS) for measuring humidity, accelerometer for measuring crack signals, and strain gauge for measuring displacement are used. For safety, after disposing of HLW in the HLW repository, access to the disposal tunnel gets blocked, making it impossible to replace or remove the monitoring sensors. So, it is necessary to evaluate the effect of the HLW repository’s environmental conditions on the monitoring sensors and enhance their durability through quantitative life evaluation and shielding. Before evaluating the life of accelerometers and strain gauges used in the HLW repository, an experimental study is conducted to determine failure modes and failure mechanisms under radiation conditions, which are unique environmental conditions of the HLW repository.