The loop thermosyphon has been designed and tested for cooling several hundreds watt of heat. This cooling system is consisted of copper block, condenser which is fabricated with tubes and fins and transport lines. In this research, operational characteristics and limitation of the loop thermosyphon were investigated as a function of fill charge ratio, thermal load, vapor temperature and effective head. The experimental results shows that the heat transfer limitation is dominated by vapor temperature and effective head. Also, the correlation for the heat transfer limitation is presented and showed good agreement. The evaporating heat transfer coefficient is affected by vapor temperature and heat flux, but the fill charge ratio and liquid head are minor factor.