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땃두릅(Oplopanax elatus Nakai) 추출물의 면역자극 활성 및 항암 증진 효과 KCI 등재

The Enhanced Effect of Oplopanax elatus Nakai on the Immune System and Antitumor Activity

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  • URLhttps://db.koreascholar.com/Article/Detail/241099
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한국식품영양학회지 (The Korean Journal of Food And Nutrition)
한국식품영양학회 (The Korean Society of Food and Nutrition)
초록

The present study is designed to explore an anti-tumor activity on crude extracts of Oplopanax elatus. Water extractions of Oplopanax elatus were performed at 100℃(OeE-100). OeE-100 doses up to 62.5 ㎍/㎖ had no cytotoxicity on the tumor cell lines in vitro. In experimental lung metastasis of colon26-M3.1 carcinoma or B16-BL6 melanoma, the prophylactic intravenous (4~100 ㎍/mouse) or oral (2 ㎎/mouse) administration of OeE-100 significantly inhibited tumor metastasis as compared with tumor controls. Peritoneal macrophages stimulated with OeE-100 produced various cytokines such as TNF-α, IL-6 and IL-12. In an analysis of NK-cell activities, i.v. administration of OeE-100 (10~100 ㎍/mouse) significantly augmented the cytotoxicity to YAC-1 tumor cells. Vaccination of mice with boiling-treated tumor cells (BT-vaccine) in combination with OeE-100 (100 ㎍/mouse) showed higher inhibitions in tumor metastasis when compared with the mice of BT-vaccine treatment. In addition, the splenocytes from OeE-100 admixed BT-vaccine immunized mice secreted a higher concentration of Th1 type cytokine such as IFN-γ. These results suggested that the OeE-100 stimulated immune system and was a good candidate adjuvant of anti-tumor immune responses.

저자
  • 허진우(유한대학 식품영양과) | Jin Woo Hur
  • 조은희(유한대학 식품영양과) | Eun Hee Cho
  • 이보경(유한대학 식품영양과) | Bo Kyung Lee
  • 이의영(산야초 농원) | Uiyoung Lee
  • 윤택준(유한대학 식품영양과) | Taek Joon Yoon Corresponding author