논문 상세보기
새로운 Aminoisoquinolinylamide 유도체의 합성 및 흑색종 저해 효능 KCI 등재
Synthesis and Melanoma Inhibitory Activity of New Aminoisoquinolinylamide Derivatives
유경호, 조혜정
- 언어KOR
- URLhttps://db.koreascholar.com/Article/Detail/257719
4,000원
한국응용과학기술학회지
(The Korean Society of Applied Science and Technology)
Vol.26 No.2 (2009.06)
pp.161-170
pp.161-170
한국응용과학기술학회(구 한국유화학회)
(The Korean Society of Applied Science and Technology (KSAST))
초록
In this work, a novel series of aminoisoquinolinylamide derivatives 1a-c and 2a-f were synthesized via several reaction steps, starting from 2-methyl-4-nitrobenzonitrile (3) and 1-chloro-5-nitroquinoline (8). And their antiproliferative activities were screened against A375 human melanoma cell line compared to Sorafenib as a reference compound. Among them, compound 1b and 1c exhibited meaningful inhibitory activities. These results demonstrated that aminoisoquinolinylamide scaffold possesses the possibility as the treatment for melanoma.
키워드
aminoisoquinolinylamidessynthesisantiproliferative activitymelanoma cell line
저자
같은 권호 다른 논문
