흑색종 세포증식 저해효능의 새로운 Benzaminoquinoline 유도체의 합성

유경호; 남봉수

논문 상세보기

흑색종 세포증식 저해효능의 새로운 Benzaminoquinoline 유도체의 합성 KCI 등재

Synthesis of New Benzaminoquinoline Derivatives with Antiproliferative Activity against Melanoma Cell Line

유경호, 남봉수

언어KOR
URLhttps://db.koreascholar.com/Article/Detail/257735

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한국응용과학기술학회지 (The Korean Society of Applied Science and Technology)

Vol.26 No.3 (2009.09)
pp.297-305

한국응용과학기술학회(구 한국유화학회) (The Korean Society of Applied Science and Technology (KSAST))

초록

Melanoma is the most serious type of skin cancer as a malignant tumor of melanocytes. In this work, the syntheses of a novel series of benzaminoquinoline derivatives 1a-c and their antiproliferative activities against A375 human melanoma cell line were described. All the compounds (IC50=0.78-1.02μM) showed superior antiproliferative activities to Sorafenib (IC50=5.58μM) as a reference compound. These results suggested that benzaminoquinoline derivatives have potentials as a therapeutic agent for the treatment for melanoma.

키워드

benzaminoquinolines syntheses antiproliferative activity melanoma cell line

저자

유경호 | Yoo, Kyung-Ho
남봉수 | Nam, Bong-Soo

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