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Quinolone 내성을 나타내는 Salmonella enterica subsp. enterica serovar Enteritidis의 유전학적 특성 KCI 등재

Characterization of Salmonella enterica subsp. enterica serovar Enteritidis Isolates Displaying Quinolone Resistance in Seoul

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

In order to investigate the resistance patterns and molecular characteristics of resistance gene of 9 NA-resistant Salmonella enterica subsp. enterica serovar Enteritidis, Total of 101 isolates were isolated from stool sampes from 2005 to 2006. Among them, 48 isolates(47.5%) were identified S. Enteritidis, 24 isolates(23.8%) S. Typhi, 8 isolates(42.5%) S. Typhimurium, 7 isolates(6.9%) S. Paratyphi A and 14 isolates (13.9%) others Salmonellas. All of S. Enteritidis were resistant to ampicillin(43.8%), ticarcillin(43.8%), streptomycin(37.5%), chloramphenicol(29.2%), tetracycline(10.4%) and nalidixic acid(18.8%), respectively. All nalidixic acid-resistance isolates represented one point mutation in the quinolone resistance determining region(QRDR) of gyrA gene. Among them, 8(89%) isolates were substituted Tyr for Ser at position amino acid 83th or 1(11%) isolate was substituted Asn for Asp at position amino acid 87th. In consequence, Continued surveillance of NA-resistance among non-Typhi S. entetica isolates is needed to mitigate the increasing prevalence of nalidixic acid resistance.

목차
I. 서론
 II. 재료 및 방법
  1. 균의 분리 및 동정
  2. 혈청형 분석
  3. 항균제 감수성시험
  4. DNA 분리
  5. Nalidixic acid 내성유전자의 분석
 III. 결 과
  1. 균 분리
  2. 항균제 내성양상
  3. NA 내성유전자의 특성
 IV. 고 찰
 V. 참고문헌
저자
  • 김은기(단국대학교 보건학과) | Eun Ki Kim
  • 오세아(단국대학교 보건학과) | Sae A Oh
  • 김연선(단국대학교 보건학과) | Yeon Seon Kim
  • 이영기(단국대학교 치과대학 구강미생물학교실) | Young Ki Lee correspondence