Inflammation functions as a double-edged sword against external stimulus. For instance, inflammation can have anti-cancer effect and simultaneously can play cancer-promoting factors. Recent studies have shown that cytokine plays an important role in tumor biology by influencing tumor growth, invasion and metastasis. We classify these cytokines by cancer type and review current knowledge of cytokines in terms of carcinogenesis. Here, we also focus on whether cytokines can act as biomarkers for early detection of oral squamous cell carcinoma (OSCC). This review will provide basis for further approach to study the role of cytokines in carcinogenesis and evaluating the possibilities of cytokines as biomarkers for cancer detection

Ⅰ. 서론
  1. 암에서 발현되는 염증성 사이토카인(Inflammatorycytokine)
  2. 자가 및 측 분비인자(Autocrine/Paracrine growtheffector)로서의 사이토카인
  3. 암세포에서 발현되는 염증성 사이토카인의 수용체(Receptor) 및 신호전달(Signaling pathway)
  4. 암 조기진단 표지자로서 염증성 사이토카인의 임상적용 가능성
  5. 구강 편평세포암종 조기진단 표지자로서 염증성 사이토카인의 임상 적용 가능성
 Ⅱ. 결론
 Ⅲ. 참고문헌

• 김도경(연세대학교 치과대학 구강병리학교실, 구강종양연구소) | Do Kyeong Kim
• 배정윤(연세대학교 치과대학 구강병리학교실, 구강종양연구소) | Jung Yoon Bae
• 박영진(연세대학교 치과대학 구강병리학교실, 구강종양연구소) | Young Jin Park
• 손화경(백석대학교 치위생학과) | Hwa Kyung Son
• 이재훈(연세대학교 치과대학 보철학교실) | Jae Hoon Lee
• 김진(연세대학교 치과대학 구강병리학교실, 구강종양연구소) | Jin Kim correspondence