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Antioxidant activity of dropwort fermented extract (DFE) was measured according to fermentation period, and liverprotective effects were examined using Sprague-Dawley rats. Total polyphenol and flavonoid contents as well as DPPH andABTS radical scavenging activities increased up to 60~80 days and then decreased slightly. Proper fermentation time forDFE was more than 60 days and less than 80 days. Administration of alcohol to rats for 10 days at 10mL/kg/day raisedserum AST, ALT, total cholesterol, and triglyceride (TG) levels, which were then lowered by DFE and sugar liquid with thesame soluble solids. While sugar liquid increased the blood lipid profile, especially TG levels, DFE had no effect due to itsantioxidant activity. When TBARS content of the DFE group in liver tissue significantly decreased in a concentration-dependent manner compared to that of the ALH group (p<0.05). Liver damage was recovered by DFE treatment and wasconfirmed by hamatoxylin-eosin staining. These results suggest that DFE has a protective effect against alcohol-inducedhepatotoxicity in SD rats.
