Since Korean ancient times, powder of Rosa rugosa Thunberg has been used as a folk remedy. This study was conducted to verify the effects of Rosa rugosa Thunberg powder on in vitro antioxidant properties and serum lipid levels of high-fat diet-induced mice from a nutritional viewpoint. In the case of Rosa rugosa Thunberg powders, measurement of TPC, ABTS radical scavenging activity of trolox, DPPH radical scavenging activity, and measured value of FRAP were higher in ethanol extract than water extracts. For LDL-cholesterol concentration, mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a high numerical value compared with other groups (p<0.05). When testing for triglyceride concentrations in blood, mice fed 10% and 20% powder of Rosa rugosa Thunberg with high-fat diets showed the lowest numerical values (p<0.05). When testing for blood insulin concentrations, the high-fat diet group showed higher levels than compared to the control group (p<0.05). When testing for blood leptin concentrations, the high-fat diet group was 5.88±3.53 ng/dL, whereas mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a blood leptin level of 10.36±5.96 ng/dL (p<0.05). Therefore, results prove that powder of Rosa rugosa Thunberg reduces triglyceride concentrations in the blood, and could be used as an excellent natural antioxidant in the future.

Abstract
 서 론
 재료 및 방법
  1. 시료
  2. 해당화 열매 분말의 일반성분 분석
  3. 항산화 활성 분석
   1) 시료 준비
   2) 총 페놀 함량의 측정(Total phenolic content, TPC)
   3) ABTS[2,2’-azinobis(3-ethylbenzothiazoline-6-sulfonicacid)] 라디칼 소거능 측정
   4) DPPH(1,1-diphenyl-2-picrylhydrazyl) 라디칼소거능측정
   5) FRAP(Ferric reducing antioxidant power)에 의한 항산화 활성 측정
  4. 동물실험
   1) 실험동물 및 사육조건
   2) 동물사료 조성
   3) 체중 변화 및 장기 무게
   4) 혈액 채취
  5. 혈중 지질 농도 분석
   1) 콜레스테롤 함량 측정
   2) HDL-cholesterol 및 LDL-cholesterol 함량 측정
    (1) HDL-cholesterol 함량 측정
    (2) LDL-cholesterol 함량 측정
   3) Triglyceride 함량 측정
  6. 혈액 내 생화학적 분석
  6. 통계처리
 결과 및 고찰
  1. 일반성분 분석
  2. 항산화 활성 분석
  3. 흰쥐의 체중 변화 및 장기 무게
  3. 혈중 지질 수준의 변화
  4. 혈액 내 생화학적 지표 및 insulin과 leptin 수준의 변화
 요약 및 결론
 References

• 최경순(삼육대학교 식품영양학과) | Kyung-Soon Choi
• 김용환(경기대학교 식품생물공학과) | Yong-Hwan Kim
• 이기원(경기대학교 기초과학연구소) | Ki-Won Lee
• 신경옥(삼육대학교 식품영양학과) | Kyung-Ok Shin Corresponding author