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구강편평상피세포암종 세포주에서 YAP의 발현 KCI 등재

The Expression of YAP in Oral Squamous Cell Carcinoma Cell Line

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

Hippo signaling is one of the signal transduction pathways revealed in Drosophila and mammalian. This signaling is known to control proliferation and growth of normal cells or cancer cells, in which many signaling proteins form a network. In this network, tumor suppressor kinases include MST and LATS while YAP and TAZ exist as oncoproteins. Combined with transcription factor, YAP the oncoprotien starts to secrete growth factors such as CTGF, FGF, and Cry61 regulating the growth of cells or the organ sizes. The YAP is also associated with the development of early embryo and the regeneration of the skin wound as well as abnormal growth of cancers in case of over-expression. Although many previous studies have found various tumors with YAP over-expressed, the expression of YAP is not yet clearly identified in oral cancer.
The aim of this study was to check the expression level of YAP in oral squamous cell carcinoma. So we performed PCR and Western blot to check YAP expression in mRNA and protein level respectively. In result, all of the 13 cell lines examined has presented the expression of YAP, and especially in HSC2 and KOSCC11 cell lines has been observed the remarkable level of expression.
In conclusion, we confirmed the overexpression of YAP cell line in oral squamous cell carcinoma, it will be a great help to the study carried out in the future. Once you understand the mechanism of oncoprotien YAP in oral cancer cells, it seems possible to research and development of targeted tumor therapy agents in oral cancer.

저자
  • 김지연(삼육대학교 동물생명공학과) | Ji Yeon Kim
  • 홍지수(서울대학교 치의학대학원 구강병리학교실, 비엠피랩) | Ji Soo Hong
  • 이재일(서울대학교 치의학대학원 구강병리학교실) | Jae Il Lee
  • 홍성두(서울대학교 치의학대학원 구강병리학교실) | Seong Doo Hong
  • 이상진(삼육대학교 동물생명공학과) | Sang Jin Lee Correspondence