CIS nations are recognized as an emerging market recently because there are abundant natural resources and a lot of investment demand. Furthermore, they are located in the middle of Europe and Asia and that make them have more strategic importance as a logistics hub. So many global companies including domestic ones began to advance into the on-site. and this tendency will be strong. On the contrary, a research in logistics environment of CIS has rarely been done. This paper provides a way of systematic approach to design logistics network in CIS with real business case and shows the analyzed result of optimization simulation that includes factors having a huge influence on the overall logistics cost.