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Methacryloxypropyl tris(trimethylsiloxy)silane과 N,N-dimethylacrylamide를 포함한 고함수 친수성 콘택트렌즈 제조에 관한 연구 KCI 등재
Studies on the hydrogel contact lens with high water content containing methacryloxypropyl tris(trimethylsiloxy)silane and N,N-dimethylacrylamide
pp.303-311
목 적: 본 연구는 고함수 하이드로젤 렌즈를 제조하기 위해 일반적으로 사용되는 콘택트렌즈의 재료와 MPTS(methacryloxypropyl tris(trimethylsiloxy)silane) 및 DMA(N,N-dimethylacrylamide)를 각각 첨가하여 중합한 후 이 재료들의 첨가 비율을 증가시켜 물리적 특성을 평가하였다. 방 법: MPTS와 DMA를 교차결합제인 EGDMA와 HEMA, NVP, MMA 그리고 개시제인 AIBN을 사용하여 캐스트 몰드법으로 공중합 하였다. 결 과: 실험결과, DMA를 첨가하여 제조한 콘택트렌즈의 함수율은 43.32~64.65%, 산소전달률(Dk)은 13.55~33.55×10(-11)(cm2/sec)(mlO2/ml×mmHg)이었다. MPTS를 첨가하여 제조한 콘택트렌즈의 경우, 함수 율은 41.02~47.62%, 산소전달률(Dk)은 13.88~20.38×10-11(cm2/sec)(mlO2/ml×mmHg)이었다. DMA가 첨가된 조합에서는 함수율이 증할수록 산소전달률(Dk)이 증가하는 경향을 보였지만 MPTS가 첨가된 조합에서는 함수율이 증가하여도 산소전달률(Dk)은 일정하게 유지되는 경향을 보였다. 결 론: 본 실험결과로 볼 때 생성된 공중합체는 고함수율을 가진 안의료용 재료로 사용될 수 있을 것으로 판단된다.
Purpose: This study, we compared the physical properties of the compositions that were mixed with basic materials of hydrogel lens and MPTS, DMA by making the high water content hydrogel lens. Increasing of MPTS and DMA, and we analyzed result using average values of physical properties of each sample. Methods: We used DMA and MPTS as an additive and copolymerized HEMA(2- hydroxyethylmethacrylate), NVP(N-vinyl-2-pyrrolidone), MMA(methyl methacrylate) with the cross-linker EGDMA(ethylene glycol dimethacrylate) and the initiator AIBN(azobisisobutyronitrile) by castmould method. Results: Measurement of the physical properties of the DMA copolymer showed that the water content was 43.32~64.65%, while the oxygen permeability showed a distribution between 13.55 and 33.55×10-11(cm2/sec)(mlO2/ml×mmHg). In cases of contact lenses with added MPTS which showed that water content was 41.02~47.62% while the oxygen permeability showed a distribution between 13.88 and 20.38×10-11(cm2/sec)(mlO2/ml×mmHg). Therefore, In the composition of DMA, the values of the oxygen transmissibility increased with increasing of water contents. In the composition of MPTS the values of the oxygen transmissibility kept constant with increasing of water contents. Conclusions: Based on the results of this study, the produced copolymer can be estimated to be suitable for use as a material for high water content contact lenses.
