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금속산화물 첨가가 다공성 calcium metaphosphate ceramic 의 생분해성과 조직공학적 골형성능에 미치는 영향 KCI 등재

Effect of Incorporation of Metallic Oxides into Calcium Metaphosphate Ceramics on its Biodegradability and Tissue Engineered Bone Regeneration Efficiency

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대한구강악안면병리학회지 (The Korean Journal of Oral and Maxillofacial Pathology)
대한구강악안면병리학회 (Korean Academy Of Oral And Maxillofacial Pathology)
초록

As a pa rt 0 1' the effort to develop a suitable scaffold for tissue-engineered bone regene ration, we modified calcium metaphosphate(CMP) ce ramic with 5 mol% Na20 or K20 to improve t he biodegradability and evaluated their effi ciency as a biodegr adable scaffold for ti ssue-engineered bone regeneration. The macroporous αiIP ceramic blocks incor porated with 5 mol% Na20 or K20 were prepa recl to have average pore size of 250 um in an inte rconnectecl framework structure The influ e nce of inco r pora tecl 5 mol% Na20 or K20 on cytotoxicity‘ cellular attachmont and t heir clifferentiation was evaluated by in vit ro analyzing sys tern. res pectively. The bioclegradability, histocompatibility, and osteogenic effect by cell-scaffolcl co nstruc ts were evalua ted by im plantation of them into subcutaneous pouches of SD-rats 0 1' SCID ITllce The incorporation of 5 mol% Na20 or K20 causecl clecrease of compressive strength without improving of biodegr adabili ty . The moclifi ed scaffolcls revea led no cy totoxic and excell ent biocompatability but osteogneic effect was recluced compa red to pure CMP ce ramic porous blocks . These res ul Ls s ugge::;t tha t the incorporation of 5 mol% Na20 0 1' K20 into pure CMP is not effective for improv ing effï ciency 0 1' scaffolcls fo1' tissue-engineered bone regeneration in terms of bioclegradabi li ty‘ physical s trength . a ncl osteogenic rege ne ra tive effect

저자
  • 박찬대(경북대학교 치과대학 구강병리학교실) | Chan Dae Park
  • 박의균(경북대학교 치과대학 구강병리학교실) | Eui Kyun Park
  • 신홍인(경북대학교 치과대학 구강병리학교실) | Hong In Shín Correspondence