Background : Insulin-like growth factor 1 (IGF-1) appears to enhance the differentiation of osteoblasts and to activate the mineralization of bone. Hence, the aim of this study was to investigate the effects of ginseng complex on the remodeling of rats tibia. Methods and Results : Ginseng complex significantly increased serum IGF-1 by 58% and 34.5% than the control, respectively. Treatment with α-amylase when manufacturing these extracts remarkably increased the concentration of IGF-1 by 63% and 36% above the control, respectively. This ways that this ginseng complex, especially α-amylase treated extracts, contained a higher level of IGF-1 secretion in the ginseng complex groups. In addition, increases of 8% in femuf length were found after 12 weeks of oral administration with ginseng complex (300mg/kg). Conclusion : These results mean that ginseng complex have beneficial effects on bone effects on bone growth via IGF-1.

• Young Ock Kim(Department of Herbal Corp Reasearch, RDA) | 김영옥
• Ji Yeon Lee(Department of Industrial Plant Science and Technology, Chungbuk National University) | 이지연
• Kyung Hun Park(Department of Herbal Corp Reasearch, RDA) | 박경훈
• Je Hun Choi(Department of Herbal Corp Reasearch, RDA) | 최재훈
• Ji Hea Yoon(Department of Herbal Corp Reasearch, RDA) | 윤지혜
• Yu Su Shin(Department of Herbal Corp Reasearch, RDA) | 신유수
• Heung Bin Lim(Department of Industrial Plant Science and Technology, Chungbuk National University) | 임흥빈
• Chun Geon Park(Department of Herbal Corp Reasearch, RDA) | 박춘근 Corresponding author