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Synergistic antibacterial effects of a combination of cephalexin and gentamicin against Streptococci isolated from dairy cows with subclinical mastitis in Gyeongnam province KCI 등재

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

This study investigated the synergistic effects of a combination of cephalexin and gentamicin (CCG) against Streptococcus spp. isolated from bovine milk. Minimum inhibitory concentrations (MICs) and fractional inhibitory concentration (FIC) index were determined for 12 bacteria isolated from 12 bovine farms in Gyeongnam province. The MIC ranges of cephalexin, gentamicin and CCG were 0.25-0.5, 0.5-2.0 and 0.06-0.125 μg/mL, respectively. In addition, the FIC index range of CCG against the isolates was 0.32-0.34, showing a synergistic effect in the checkboard assay. In conclusion, CCG has a high antibacterial activity against Streptococcus isolates and may be utilized in the treatment of bovine streptococcal mastitis.

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ACKNOWLEDGEMENTS
 REFERENCES
저자
  • Chun-Nam Cha(Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University)
  • Eun-Kee Park(Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University)
  • Chang-Yeul Yoo(Department of Smart Information Convergence, Gyeongnam Provincial Namhae College)
  • Suk Kim(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University)
  • Hu-Jang Lee(Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University) Corresponding Author