엉겅퀴에서 분리 정제한 Silymarin 의 사람 Low Density Lipoprotein 에 대한 항산화 효과

이백천; 진성현; 조경자; 김동석; 류병호

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엉겅퀴에서 분리 정제한 Silymarin 의 사람 Low Density Lipoprotein 에 대한 항산화 효과 KCI 등재

Antioxidative Effect of Silymarin Purified from Silybum Marianum on Modification of Human Low Density Lipoprotein

이백천, 진성현, 조경자, 김동석, 류병호

언어KOR
URLhttps://db.koreascholar.com/Article/Detail/341808

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한국식품위생안전성학회지 (Journal of Food Hygiene and Safety)

Vol.12 No.1 (1997.03)
pp.1-8

한국식품위생안전성학회 (Korean Society of Food Hygiene and Safety)

초록

This study was pcrformed to evaluate the antioxidant activity of silymarin against human low density lipoproteins(LDL) oxidation. Silymarin extracted from Silybum marianum was successively purified with solvent fractionation and followed by silica gel column chromatography. The active substances were separated by HPLC and the isolated active substances, silymarin were identified by IR, NMR, GC-MS as silymarin. Silymarin inhibited at the 5 uM Cu^(2+)-mediated oxidation of human low density lipoprotein (LDL) in a dose dependent manner. Silymarin completely inhibited LDL oxidation at 50 ug/ml concentration. These findings suggest that silymarin may protect LDL against oxidation in atherosclerotic lessions.

저자

이백천(순천당제약(주)) | Baek-Chen Lee
진성현(부산광역시 보건환경연구원) | Sung-Hyun Jin
조경자(경성대학교 가정학과) | Kyung-Ja Cho
김동석 | Dong Suck Kim
류병호(경성대학교 식품공학과) | Beung-Ho Ryu

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