For centuries, Lentinula edodes called “Pyogo” in Korea has been cultivated as a high-grade edible mushroom in Asia. This is known as medicinal mushroom for cold prevention in oriental medicine. In the world market, this mushroom of Lentinula edodes is introduced as representative edible and medicinal mushroom in Asia. As consumer interest increases, Asian Lentinula edodes market is also growing. There is a record that Korea has already been used as a gourmet food on the royal meal table for the king in the 15th century Joseon Dynasty. In Korea's famous oriental book, it is cooked with many traditional foods because of the pharmaceutical efficacy of this mushroom. For long time ago, difference in cultivation as well as in mushroom growth of Lentinula edodes has studied in Korea. Recent advances in cultivation of selected high quality mushroom studied from substrate optimization using log and sawdust of oak tree. Cultivation of Lentinula edodes strain research controlled the production of large quantity of various substrate conditions. This mushroom mycelia and fruit-body were cultivated in log of oak tree and sawdust substrate cultivation in types of bioreactors. According to compared cultivation method, it presented the optimistic condition for the amount production of various Lentinula edodes strain in Korea.