This study evaluated the effect of reduced glutathione (GSH) for the reduction of stress and inflammatory response in calves inoculated with foot-and-mouth disease (FMD) vaccine. Twenty-five calves were divided into five groups of 5 calves. The negative control (NC) did not receive any vaccination or drug treatment. The positive control (PC), GSH-25, GSH-50 and GSH-100 were intramuscularly injected with GSH at concentrations of 0, 25, 50 and 100 mg / 10 kg body weight (BW), respectively, for 3 days after FMD vaccination. On day 3, 5 and 7 post-treatment, the serum cortisol and tumor necrosis factor- α (TNF-α) levels in GSH-50 and GSH-100 were significantly decreased compared with those in PC (p < 0.05). However, there was no significant difference in the serum cortisol and TNF-α levels between GSH-100 and NC 3 and 5 days post-treatment, and between GSH-50, GSH-100, and NC 7 days post-treatment. The results from this study suggest that treatment of 50 mg / 10 kg BW GSH for 3 days is useful for the reduction of stress and inflammatory response caused by FMD vaccination in calves.

• Chun-Nam Cha(Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University)
• Won-Seok Chae(Schools of Life-Chemistry, Daejin University)
• Eun-Kee Park(Department of Medical Humanities and Social Medicine, College of Medicine, Kosin University)
• Chang-Yeul Yoo(Department of Smart Information and Convergence, Gyeongnam Provincial Namhae College,)
• Song-Ee Son(Institute of Animal Medicine and College of Veterinary Medicine, Gyeongsang National University)
• Suk Kim(Institute of Animal Medicine and College of Veterinary Medicine, Gyeongsang National University,)
• Hu-Jang Lee(Institute of Animal Medicine and College of Veterinary Medicine, Gyeongsang National University,) Corresponding Author