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Inflammation-regulatory effects and modulation of mitochondrial metabolism by domestic rice bran oil in RAW 264.7 macrophages
Previous studies demonstrated that rice bran oil has an anti-inflammatory effect. The current study investigated if the immune responses and energy metabolism phenotypes were affected by rice bran oil. Rice bran oil and palm oil, which served as an experimental control, were treated to RAW 264.7 macrophages respectively, followed by LPS stimulation so as to quantify the production of pro-inflammatory cytokines such as IL-6 and TNF-α. The expression of surface markers i.e. CD 80, CD 86 and MHC-classⅡ and mitochondrial metabolism phenotypes were also tested.
The data exhibited rice bran oil suppressed inflammatory responses and mitochondrial metabolism were modulated by rice bran oil. These results warrant the necessity for the compositional and/or mechanistic studies to elucidate the details.
