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Enhancement of Astaxanthin Wound Healing Ability by Complexation with Cyclodextrin in Sacran Hydrogel

  • 언어ENG
  • URLhttps://db.koreascholar.com/Article/Detail/352889
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한국산업식품공학회 (Korean Society for Food Engineering)
초록

Astaxanthin(Ast) is considered a powerful antioxidant. However, the efficacy of Ast is limited due to its poor water solubility and stability. To enhance the properties of Ast, 2-hydroxypropyl-γ-cyclodextrin(HPγ-CyD) can be used through complexation. In this study, we investigated the wound healing ability of Ast/HP-γCyD(Ast/HP-γ-CyD) complex in sacran-based hydrogel. HP-γ-CyD played an important role to increase the elastic modulus of the sacran-based hydrogel with high swelling ability. Unusually, the Ast/HP-γ-CyD complex in sacran-based hydrogel provided the highest wound healing ability in mice. These results suggest that the Ast/HP-γ-CyD complex in sacran-based hydrogel has the potential for use as a new transdermal therapeutic system to promote the wound-healing process

저자
  • Jing GI Bak(Department of Advanced Chemicals and Engineering, Chonnam National University)
  • Jin Kim(Research Center for Healthcare-Biomedical Engineering,, Chonnam National University)