Bovine papillomaviruses (BPVs) are DNA oncogenic viruses that belong to the Papillomavirus genus. The purposes of the present study were to histopathologically diagnose skin warts on Korean native cattle from Jeju Island and to detect the presence of BPVs from tissue samples of the skin warts, using the polymerase chain reaction (PCR) assay. The sites of 10 skin wart involvement were the head (40%: 10% were in both the head and neck), shoulder (30%), neck (20%), and tail (20%), including the perineum. All skin warts were confirmed as fibropapillomas, as characterized by the abundant proliferating fibrous tissue in the dermis and increased epithelial covering of variable thickness. According to the PCR analysis, five out of 10 (50%) cattle were positive for BPV-1, and six (60%) cattle were positive for BPV-2. Two cattle were positive for both BPV-1 and BPV-2. To the best of our knowledge, this is the first study of BPV-1 and BPV-2 infections of skin warts from Korean native cattle in Korea.

Abstract
 INTRODUCTION
 MATERIALS AND METHODS
  Study subjects
  Histopathology
  Polymerase chain reaction analyses
 RESULTS
  Clinical data
  Gross and histopathologic findings
  PCR analysis
 DISCUSSION
 REFERENCES

• Young-Jin Hong(College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University)
• Jae-Hoon Kim(College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University) Corresponding Author