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RAW 264.7세포에 감염시킨 Salmonella gallinarum에 대한 나트륨염 복합조성물의 항균효과 KCI 등재

Antibacterial effect of sodium salt mixture against Salmonella gallinarum infection in RAW 264.7 cells

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예방수의학회지 (Journal of Preventive Veterinary Medicine)
한국예방수의학회(구 한국수의공중보건학회) (The Korean Society of Preventive Veterinary Medicine)
초록

The present study was investigated the antibacterial effect of several sodium salts and the sodium salt mixture composed with sodium chlorate, sodium azide and sodium cyanide on Salmonella gallinarum (S. gallinarum) infection in murine derived macrophage RAW 264.7 cells. In the infection assay of S. gallinarum in macrophage cells pretreated with 15 mM sodium chlorate, 0.3 mM sodium cyanide, 0.3 mM sodium azide and the sodium salt mixture (15 mM sodium chlorate, 0.3 mM sodium cyanide, 0.3 mM sodium azide), respectively, the numbers of S. gallinarum in all treated-groups tended to decrease in the process of time after treatment, but the group treated with sodium cyanide was no significant difference compared with control. After 24 hours of treatment, the number of S. gallinarum in sodium azide (p<0.05), sodium chlorate (p<0.001) and the sodium salt mixture (p<0.001) treated-group was significantly decreased compared with control, and that in the sodium salt mixture treated-group was decreased the higher than all groups. The results of this study demonstrated that the sodium salt mixture composed with sodium chlorate, sodium azide and sodium cyanide, has the antimicrobial activity for S. gallinarum and may be beneficial on the control of intracellular pathogens.

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저자
  • 임정주(경상대학교 수의과대학(생명과학연구원)) | Jeong-Ju Lim (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
  • 차춘남(경상대학교 공과대학 산업시스템공학부(공학연구원)) | Chun-Nam Cha (Engineering Research Institute, Department of Industrial Systems Engineering, Gyeongsang National University)
  • 김대근(경상대학교 수의과대학(생명과학연구원)) | Dae-Geun Kim (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
  • 이진주(경상대학교 수의과대학(생명과학연구원)) | Jin-Ju Lee (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
  • 이여은(경상대학교 보건대학원 환경위생학과) | Yeo Eun Lee (Department of Environmental Health, Graduate School of Public Health, Gyeongsang National University)
  • 손송이(경상대학교 수의과대학(생명과학연구원)) | Song-Ee Son (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
  • 김석(경상대학교 수의과대학(생명과학연구원)) | Suk Kim (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University)
  • 이후장(경상대학교 수의과대학(생명과학연구원)) | Hu-Jang Lee (Research Institute of Live Sciences, College of Veterinary Medicine, Gyeongsang National University) Correspondence