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산마늘과 벌개미취 추출물의 α-glucosidase 저해 활성 평가

Evaluation of α-glucosidase Inhibition activity of Allium victorialis and Aster koraiensis Extracts

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한국약용작물학회 (The Korean Society of Medicinal Crop Science)
초록

Background : Medicinal wild vegetables refer to wild medicinal plants whose aerial parts are edible. Recent researches for developing a functional food product from medicinal wild vegetables have been actively reported. The objective of this study is to test anti-diabetic activity of 2 medicinal wild vegetables, Allium victorialis and Aster koraiensis.
Methods and Results : The medicinal wild vegetables were extracted using water and ethanol. Several medicinal wild vegetables were screened for anti-diabetic activity using α-glucosidase inhibitor screening test (colorimetric). It utilizes the ability of an active α-glucosidase to cleave a synthetic substrate and releasing a chromophore (OD 410 ㎚). In the presence of an α-glucosidase specific inhibitor, the enzymatic activity is greatly reduced which is detected by a decrease of absorbance readings. The α-glucosidase inhibitory activity of acarbose was compared with wild vegetables extracts at 1 ㎎/㎖. And A. victorialis and A. koraiensis extracts were selected. α-glucosidase inhibitory activities of A. victorialis and A. koraiensis extracts were confirmed in various concentration.
Conclusion : These results suggest that A. victorialis and A. koraiensis could be good candidates for anti-diabetic material.

저자
  • 이은영(농촌진흥청 국립원예특작과학원 인삼특작부) | Eun Young Lee
  • 서경혜(농촌진흥청 국립원예특작과학원 인삼특작부) | Kyung Hye Seo
  • 이승은(농촌진흥청 국립원예특작과학원 인삼특작부) | Seung Eun Lee
  • 최재훈(농촌진흥청 국립원예특작과학원 인삼특작부) | Je Hun Choi
  • 장귀영(농촌진흥청 국립원예특작과학원 인삼특작부) | Gwi Yeong Jang
  • 김형돈(농촌진흥청 국립원예특작과학원 인삼특작부) | Hyung Don Kim Corresponding author