Most of chemical plant are using toxic and dangerous materials, inflammable and poisonous. There are many accidental dangers by escaping of fire, explosive and poisonous materials in case of high temperature and pressure. The accidents lead to taking employer's and local people's life and environmental contamination. Therefore, 27 small-medium chemical plant, which size is 30∼200 employees out of safety management agent in the area of A was selected in this study. The problems of safety management and several countermeasures at the chemical plants was indicated through the analyzed data. Prior to this analysis, top managers' concerns, equipment maintenance for the safety management are needed. For the future, calamity prevention countermeasures by industrial disaster analysis are needed and active safety management programs are investigated for the industrial disaster prevention and productivity enhancement at the chemical plant.